Finding the perfect slice in Tupelo, MS, is more than just a quest for cheese and toppings—it’s about discovering a flavor experience that leaves a lasting impression. Having explored the local pizza scene extensively, I can attest that Tupelo offers a surprising variety of pizzerias, each with its own unique spin on this beloved classic. Whether you crave a thin crust that crisps just right or a deep-dish delight packed with toppings, Tupelo’s pizza joints deliver options that satisfy every craving.
What makes this list especially valuable is the commitment to quality and authenticity found in these local favorites. From cozy neighborhood spots to well-loved chains, each offers something special. If you’re searching for the best pizza in Tupelo, MS, this guide will navigate you through the top contenders, ensuring you make an informed choice. Prepare to indulge in some of the tastiest slices the city has to offer.
Where to find the best pizza in Tupelo, MS
Here are some of the top spots to find the best pizza in Tupelo, MS:
- The Lost Pizza Company
- Vanelli’s Bistro
- Tellini’s
- Foxs pizza den
- PYRO’S Fire Fresh Pizza
- Little Caesars
- Papa Johns Pizza
- Papa Johns Pizza
- Sbarro
- Chuck E. Cheese
1. The Lost Pizza Company
Walk into The Lost Pizza Company and you’re greeted with walls that tell stories, a menu that dares you to explore, and a vibe that makes you want to linger. It’s not your average pizza joint—this place has character. Voted best pizza in Tupelo for a decade, they’ve clearly earned their stripes.
What stood out to me was the balance they strike between laid-back charm and serious flavor. Their “Mississippi Meat” pizza brings together bold, smoky notes that reflect the local palate. It’s a go-to if you’re seeking something hearty and satisfying.
Vegetarian options like the “Happy Hippie” show they care about inclusivity, while the crusts—thin, thick, gluten-free—are expertly done and never an afterthought. If pizza isn’t the mood, their pasta and sandwiches easily hold their own.
Whether you’re craving classic comfort or inventive combos, this spot delivers on both taste and atmosphere. It’s where pizza feels personal.
2. Vanelli’s Bistro
Vanelli’s Bistro is where tradition meets taste in the heart of Tupelo. With roots tracing back to Athens, Greece, this family-run spot has been serving scratch-made Greek and Italian fare since 1975. The atmosphere feels like a warm invitation to slow down and savor.
What makes Vanelli’s stand out is its commitment to authenticity. Their pizzas are crafted with care, using fresh ingredients and time-honored techniques. The “Greek Veggie” pizza is a standout—loaded with olives, tomatoes, and feta, it’s a flavorful nod to their heritage.
For something richer, the “Vanelli’s Special” blends savory meats and vegetables on a perfectly crisp crust. Vegetarian, vegan, and gluten-free options make it easy to find something that fits your preferences.
Dining here feels like being part of a story—one that’s been told through generations and still tastes fresh.
3. Tellini’s
Tellini’s feels like the kind of place you stumble upon—and then keep going back to. It’s modest, with a casual setting, but don’t let the simplicity fool you. The kitchen turns out pizzas that speak to flavor and consistency, two qualities that matter most when you’re judging a pie.
I found their crust to be perfectly balanced—not too thick, not paper-thin—and their sauce leans toward a classic, tangy blend. The “Tuscan Veggie” pizza is especially worth mentioning, featuring roasted vegetables that don’t overpower but complement the cheese and herbs just right.
They keep things straightforward, and that’s part of the charm. The portions are generous, and the service is quick without sacrificing quality. It’s ideal for a lunch stop or a laid-back dinner.
With vegetarian-friendly options and familiar flavors, Tellini’s delivers a solid pizza experience that’s easy to enjoy and hard to forget.
4. Foxs pizza den
Fox’s Pizza Den offers a casual, family-friendly atmosphere where pizza is taken seriously. Located conveniently on Coley Road, it’s a favorite for locals seeking quick, satisfying meals with a touch of Italian and American influence. Their menu showcases versatility, making it easy to find something for everyone.
During my visit, I enjoyed their “The Den’s Special”, a hearty pizza topped with sausage, pepperoni, and fresh vegetables. The crust is consistently crisp and flavorful—a hallmark of Fox’s quality.
What sets Fox’s apart is its commitment to quality ingredients and reliable service. The wide variety of pizza options, from classic to inventive, ensures each visit feels fresh and satisfying.
For a dependable slice that hits all the right notes, Fox’s Pizza Den remains a top choice in Tupelo.
5. PYRO’S Fire Fresh Pizza
PYRO’S Fire Fresh Pizza brings a modern twist to the Tupelo pizza scene. With its sleek interior and build-your-own concept, it’s more than just a meal—it’s a personalized experience. From the moment you walk in, the energy feels fresh, fast, and inviting.
What makes PYRO’S stand out is its customizable pizzas with a wide range of fresh toppings and sauces. You’re handed control, and the results are consistently satisfying. I opted for a thin crust with roasted chicken, spinach, and spicy red sauce—a combination that balanced heat and flavor beautifully.
The crust is crisp, the ingredients are vibrant, and the service is quick without feeling rushed. For those who want pizza their way, PYRO’S delivers with style and substance.
6. Little Caesars
Little Caesars is known for its quick service and hot, fresh pizza at an affordable price. Located conveniently in Tupelo, it’s the perfect spot for a family or group looking for a satisfying meal without a long wait. The straightforward menu focuses on delivering reliable, comfort-food favorites.
My go-to order is the Hot-N-Ready pepperoni pizza. It’s always fresh and ready to go, making it ideal for a quick lunch or dinner. The crust is crispy, the toppings generous, and the flavor consistently satisfying.
What makes Little Caesars stand out is its emphasis on efficiency and value. It’s a dependable choice when you want a classic pizza experience without fuss or delay. Perfect for those quick and tasty bites on the go.
7. Papa Johns Pizza
Papa Johns Pizza, located on W Main Street in Tupelo, consistently delivers on its promise of better ingredients and better flavor. The crust is unmistakably fresh, the sauce has a subtle tang, and the toppings come generously layered. It’s a spot that never skimps on quality.
One night, I grabbed a carryout of their The Works pizza—perfectly balanced with savory vegetables and smoky beef. It was piping hot, every slice rich with texture and taste. Papa Johns feels crafted, not mass-produced.
For a reliable pick, the Original Cheese or Garden Fresh pizza fits the bill. The crisp edge and bold tomato base showcase what makes this place stand out in the Tupelo pizza scene.
If you want a sit-down meal or quick delivery, Papa Johns is a solid choice for a straightforward, flavor-first pizza experience.
8. Papa Johns Pizza
Papa Johns Pizza on Symphony Lane doesn’t play with quality—it builds its reputation on fresh dough, tangy signature sauce, and premium toppings that hold up whether you’re grabbing a slice during a busy lunch or settling in for dinner. It’s straightforward pizza without the gimmicks, and it hits the spot.
The Garden Fresh Pizza deserves a mention; it’s vibrant, crisp, and generously portioned. If you’re after something more layered, the Tuscan Six Cheese delivers big on flavor without being heavy. Both are made fresh, which is why regulars keep coming back.
I swung by with a friend between errands, grabbed a carryout order, and got just what we needed—fast service, clean surroundings, and a pizza that wasn’t just hot, but consistent. No surprise Papa Johns is a Tupelo staple.
9. Sbarro
Walk into Sbarro at the Barnes Crossing Mall, and the aroma of a classic New York slice hits instantly. It’s no frills, just honest pizza with a bold edge. The crust is hand-stretched daily, topped with a tangy San Marzano-style sauce and finished with 100% whole milk mozzarella.
On my last visit, I grabbed their XL NY Pepperoni Slice. It was crisp at the edges, chewy in the center, and balanced—not drowned in grease or overwhelmed by toppings. It tasted like a slice made for lunchtime hustle, not indulgent excess.
What makes Sbarro different is consistency. Their pizza holds up—not just in flavor but in its simple, quality-driven approach. If you’re after a slice that feels like it belongs on a NYC street corner, this is it.
Skip the fancy options and go straight for the Cheese Slice or Pepperoni XL. They reflect Sbarro’s legacy and are easily among Tupelo’s most dependable pies.
10. Chuck E. Cheese
Chuck E. Cheese in Tupelo offers a unique blend of family fun and classic pizza enjoyment. Known for its lively arcade games and entertainment, it’s a place where kids can burn off energy while parents relax with a slice or two. The atmosphere is lively, colorful, and designed with families in mind.
During my visit, I found their cheese pizza to be surprisingly satisfying—crisp, cheesy, and perfect for sharing. The menu also features wings, fresh salads, and kid-friendly treats like Dippin’ Dots and giant cookies, adding to the fun experience.
What sets Chuck E. Cheese apart is its focus on creating a memorable family outing. The pizza may be simple, but it’s well-made and complements the energetic environment. It’s an ideal spot for birthday parties or casual family dinners.
For a quick, satisfying meal amid entertainment, the pizza here offers a reliable, family-friendly choice that keeps everyone happy.
More Things to Try in Tupelo, MS
Frequently Asked Questions
Where can I find the best pizza in Tupelo?
Many locals recommend The Lost Pizza Company and Vanelli’s Bistro for their quality ingredients and consistent flavor. Both offer dine-in and takeout options.
Are there any pizza places in Tupelo that offer halal or vegetarian options?
While halal options are limited, several restaurants like PYRO’S Fire Fresh Pizza and Tellini’s allow you to customize your pizza with vegetarian toppings and sauces. Always check with the staff for ingredient details.
Which pizza places in Tupelo offer delivery?
Major chains like Domino’s Pizza, Papa Johns, and Pizza Hut provide delivery services. Some local spots may offer delivery through third-party apps like DoorDash or Uber Eats.
Is there a pizza place in Tupelo suitable for families with kids?
Chuck E. Cheese is designed with families in mind, offering arcade games and a kid-friendly menu. It’s a popular choice for birthday parties and casual outings.
Which pizza restaurants in Tupelo have gluten-free crusts?
PYRO’S Fire Fresh Pizza and Papa Johns offer gluten-free crust options. Be sure to confirm preparation practices if you have dietary restrictions.
Are there any late-night pizza spots in Tupelo?
Chains like Domino’s and Pizza Hut typically stay open late, especially on weekends. Check their hours online before heading out.
Do any Tupelo pizza places offer dine-in service?
Yes, most local favorites such as Vanelli’s Bistro, Tellini’s, and Fox’s Pizza Den offer dine-in seating with a casual atmosphere.
Which pizza places in Tupelo are budget-friendly?
Little Caesars and Sbarro are known for affordable pricing and quick service. They’re ideal for a fast meal without compromising taste.